Who has or will be the biggest threat of the 21st Century?

By the Middle East I was referring to the rather obvious instability of relations between countries such as Iran and Israel both of whom are nuclear capable and who could not only, potentially upset global economy but also insight a war that forces the western world to intervene before it spreads.

I made a direct option for Al qaeda.

These are not my opinions I wanted the peoples opinion. I personally think America is the biggest Antagonist in this world and if they keep poking the hornets nest they will get stunned.