Is it normal to be depressed even on meds?

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  • That's correct but it is possible to be intolerant of anti-depressants. It's called Treatment Resistant Depression. I was just wondering why it was so sudden and whether anyone can relate to the situation. Hopefully, I would not have to increase my dosage as I was fine with my current one. Thanks for your reply.

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    • Oh, I guess I wasn't very clear. I meant that for some medications, it's not possible to develop a tolerance *as a result of using them*. You could still become tolerant (or intolerant) as a result of other factors for such medications. It's just not quite the same as tolerance in habit forming drugs.

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