Is it normal to be depressed even on meds?

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  • Honestly, I'm not sure why your medication is not doing the trick for you any more. There could be many variables which might be affecting your situation. Has anything about your situation changed recently?

    You said it 'suddenly changed its effect' which, to me (not a medical professional), seems unusual, so that's why I recommended you see your doctor about it. Also, I've never taken an anti-depressant, so I have no personal experience to share. I do suffer from severe and chronic anxiety, though, and I understand how not feeling well can affect motivation levels and sleep patterns, among other things. I take medication for it too, but anti-anxiety meds are a lot different than anti-depressants.

    At least you are taking a holistic approach to your depression and combining medication with therapy. Many people seem to be under the impression medication alone will cure them.

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    • I must have grown intolerance much like any other medication taken for a long period. No, my situation has been fairly uneventful which is great but it just bothers me why I react differently. Thanks.

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      • I already told bugsforbreakfast this, but I'll say it again: it is not possible to form a tolerance to all medication. It seems like a lot of people don't know that. For example, the effectiveness of acetaminophen (Tylenol) doesn't decrease with frequent use. I'm not sure about antidepressants. I know that there's a bit of evidence for tolerance in certain tricyclic antidepressants, but I'm not sure about SSRIs, which are more commonly used these days. I'll get back to you, if you like.

        That said, brains are complicated, and it's possible for other factors to make it so that a medication is no longer effective for a patient, even when tolerance isn't possible. It's not always terribly predictable. Bodies change. Talk to your doctor about changing medication or increasing your dose. There's something to be said for both options.

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        • That's correct but it is possible to be intolerant of anti-depressants. It's called Treatment Resistant Depression. I was just wondering why it was so sudden and whether anyone can relate to the situation. Hopefully, I would not have to increase my dosage as I was fine with my current one. Thanks for your reply.

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          • Oh, I guess I wasn't very clear. I meant that for some medications, it's not possible to develop a tolerance *as a result of using them*. You could still become tolerant (or intolerant) as a result of other factors for such medications. It's just not quite the same as tolerance in habit forming drugs.

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