Is it normal isolation causes inability to bond

I have basically been isolated from any real emotional contact for the better part of a decade. Other than small talk in day to day business I haven't had any meaningful contact at all. Now no matter how someone treats me, either kindly, lovingly pushy or outright ignoring me or mean I feel disengaged. I write them off as disingenuous and I don't, won't or can't connect.

Is it possible the isolation has made it impossible to have human relationships other than the most superficial? I can't take someones words or actions at face value. I simply don't trust their words or their actions no matter how stable and consistent they are.

Have I lost my mind as a result of this isolation? Can i ever return to being human?