In the reward circuit, just as in the case of other drugs, more dopamine is released. As with opiates, this paradoxical increase is explained by the fact that the dopaminergic neurons in this circuit do not have CB1 receptors, but are normally inhibited by GABAergic neurons that do have them. The cannabis removes this inhibition by the GABA neurons and hence activates the dopamine neurons.
Basically smoking raises your GABA lvl witch the side effect is rapid change in blood pressure and a hand full of other things. For all the people that experience this if you were to take a GABA supplement I would almost guarantee your outcome would be a blackout.
Have you ever passed out/ blacked out from smoking weed?
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In the reward circuit, just as in the case of other drugs, more dopamine is released. As with opiates, this paradoxical increase is explained by the fact that the dopaminergic neurons in this circuit do not have CB1 receptors, but are normally inhibited by GABAergic neurons that do have them. The cannabis removes this inhibition by the GABA neurons and hence activates the dopamine neurons.
Basically smoking raises your GABA lvl witch the side effect is rapid change in blood pressure and a hand full of other things. For all the people that experience this if you were to take a GABA supplement I would almost guarantee your outcome would be a blackout.